Respiratory Syncytial Virus Limits α Subunit of Eukaryotic Translation Initiation Factor 2 (eIF2α) Phosphorylation to Maintain Translation and Viral Replication

The impact of respiratory syncytial virus (RSV) on morbidity and mortality is significant in that it causes bronchiolitis in infants, exacerbations in patients with obstructive lung disease, and pneumonia in immunocompromised hosts. RSV activates protein kinase R (PKR), a cellular kinase relevant to...

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Bibliographische Detailangaben
Hauptverfasser: Groskreutz, Dayna J., Babor, Ellen C., Monick, Martha M., Varga, Steven M., Hunninghake, Gary W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2010
Schlagworte:
Protein Synthesis and Degradation
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2911276/
https://ncbi.nlm.nih.gov/pubmed/20519500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.077321
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