Combined Paracrine and Endocrine AAV9 mediated Expression of Hepatocyte Growth Factor for the Treatment of Renal Fibrosis

In chronic renal disease, tubulointerstitial fibrosis is a leading cause of renal failure. Here, we made use of one of the most promising gene therapy vector platforms, the adeno-associated viral (AAV) vector system, and the COL4A3-deficient mice, a genetic mouse model of renal tubulointerstitial fi...

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Detalhes bibliográficos
Main Authors: Schievenbusch, Stephanie, Strack, Ingo, Scheffler, Melanie, Nischt, Roswitha, Coutelle, Oliver, Hösel, Marianna, Hallek, Michael, Fries, Jochen WU, Dienes, Hans-Peter, Odenthal, Margarete, Büning, Hildegard
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2010
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2911253/
https://ncbi.nlm.nih.gov/pubmed/20424598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2010.71
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