A mouse embryonic stem cell bank for inducible overexpression of human chromosome 21 genes

BACKGROUND: Dosage imbalance is responsible for several genetic diseases, among which Down syndrome is caused by the trisomy of human chromosome 21. RESULTS: To elucidate the extent to which the dosage imbalance of specific human chromosome 21 genes perturb distinct molecular pathways, we developed...

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Hlavní autoři: De Cegli, Rossella, Romito, Antonio, Iacobacci, Simona, Mao, Lei, Lauria, Mario, Fedele, Anthony O, Klose, Joachim, Borel, Christelle, Descombes, Patrick, Antonarakis, Stylianos E, di Bernardo, Diego, Banfi, Sandro, Ballabio, Andrea, Cobellis, Gilda
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2010
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Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2911112/
https://ncbi.nlm.nih.gov/pubmed/20569505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/gb-2010-11-6-r64
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