N-Glycosylation of Carnosinase Influences Protein Secretion and Enzyme Activity: Implications for Hyperglycemia

OBJECTIVE: The (CTG)(n) polymorphism in the serum carnosinase (CN-1) gene affects CN-1 secretion. Since CN-1 is heavily glycosylated and glycosylation might influence protein secretion as well, we tested the role of N-glycosylation for CN-1 secretion and enzyme activity. We also tested whether CN-1...

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Détails bibliographiques
Auteurs principaux: Riedl, Eva, Koeppel, Hannes, Pfister, Frederick, Peters, Verena, Sauerhoefer, Sibylle, Sternik, Paula, Brinkkoetter, Paul, Zentgraf, Hanswalter, Navis, Gerjan, Henning, Robert H., Van Den Born, Jacob, Bakker, Stephan J.L., Janssen, Bart, van der Woude, Fokko J., Yard, Benito A.
Format: Artigo
Langue:Inglês
Publié: American Diabetes Association 2010
Sujets:
Pathophysiology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2911063/
https://ncbi.nlm.nih.gov/pubmed/20460427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db09-0868
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