Modulation of Notch-1 Signaling Alleviates Vascular Endothelial Growth Factor–Mediated Diabetic Nephropathy

OBJECTIVE: Disturbances in podocytes are typically associated with marked proteinuria, a hallmark of diabetic nephropathy. This study was conducted to investigate modulation of Notch-1 signaling in high glucose (HG)-stressed human podocytes and in a diabetic animal model. RESEARCH DESIGN AND METHODS...

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Detalhes bibliográficos
Main Authors: Lin, Chun-Liang, Wang, Feng-Sheng, Hsu, Yen-Chen, Chen, Cheng-Nan, Tseng, Min-Jen, Saleem, Moin A., Chang, Pey-Jium, Wang, Jeng-Yi
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2010
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2911050/
https://ncbi.nlm.nih.gov/pubmed/20522599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db09-0663
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