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Self-targeting by CRISPR: gene regulation or autoimmunity?

CRISPR/Cas is a recently discovered prokaryotic immune system, which is based on small RNAs (“spacers”) that restrict phage and plasmid infection. It has been hypothesized that CRISPRs can also regulate self gene expression by utilizing spacers that target self genes. By analyzing CRISPRs from 330 o...

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Detalles Bibliográficos
Main Authors: Stern, Adi, Keren, Leeat, Wurtzel, Omri, Amitai, Gil, Sorek, Rotem
Formato: Artigo
Idioma:Inglês
Publicado: 2010
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2910793/
https://ncbi.nlm.nih.gov/pubmed/20598393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tig.2010.05.008
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