LP-211 is a brain penetrant selective agonist for the serotonin 5-HT(7) receptor

We have determined the pharmacological profile of the new serotonin 5-HT(7) receptor agonist N-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide (LP-211). Radioligand binding assays were performed on a panel of 5-HT receptor subtypes. The compound was also evaluated in vivo by examining it...

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Autori principali: Hedlund, Peter B., Leopoldo, Marcello, Caccia, Silvio, Sarkisyan, Gor, Fracasso, Claudia, Martelli, Giuliana, Lacivita, Enza, Berardi, Francesco, Perrone, Roberto
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2910240/
https://ncbi.nlm.nih.gov/pubmed/20600619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neulet.2010.06.036
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