Necrosis related HIF-1α expression predicts prognosis in patients with endometrioid endometrial carcinoma

BACKGROUND: Hypoxia inducible factor 1α (HIF-1α) plays an essential role in the adaptive response of cells to hypoxia and is associated with aggressive tumour behaviour. We have shown p27(kip1), which is generally reduced in endometrial cancer, to be re-expressed in hypoxic regions. This possibly co...

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Bibliographic Details
Main Authors: Seeber, Laura MS, Horrée, Nicole, van der Groep, Petra, van der Wall, Elsken, Verheijen, René HM, van Diest, Paul J
Format: Artigo
Language:Inglês
Published: BioMed Central 2010
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2909981/
https://ncbi.nlm.nih.gov/pubmed/20565904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-10-307
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