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The Therapeutic Mode of Action of 4-Aminopyridine in Cerebellar Ataxia
Episodic ataxia type 2 (EA2) is a hereditary cerebellar ataxia associated with mutations in the P/Q-type voltage-gated calcium (Ca(2+)) channels. Therapeutic approaches for treatment of EA2 are very limited. Presently, the potassium (K(+)) channel blocker 4-aminopyridine (4-AP) constitutes the most...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Society for Neuroscience
2010
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2909847/ https://ncbi.nlm.nih.gov/pubmed/20505092 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3582-09.2010 |
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