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Rescue of Renal Hypoplasia and Cystic Dysplasia in Bcl-2 −/− Mice Expressing Bcl-2 in Ureteric Bud Derived Epithelia

Bcl-2 is the founding member of a family of proteins that influence apoptosis. Loss of bcl-2 results in renal hypoplasia/cystic dysplasia at birth. Here we examined whether reexpression of bcl-2 throughout the ureteric bud and its derived epithelia would restore a normal renal phenotype in bcl-2 −/−...

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Bibliografische gegevens
Hoofdauteurs: Kondo, Shuji, Oakes, Mason G, Sorenson, Christine M
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2008
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2909767/
https://ncbi.nlm.nih.gov/pubmed/18729219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/dvdy.21678
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