Reversible model of RNA toxicity and cardiac conduction defects in myotonic dystrophy

Myotonic dystrophy (DM1), the most common muscular dystrophy in adults, is caused by an expanded (CTG)(n) tract in the 3′ UTR of the gene encoding myotonic dystrophy protein kinase (DMPK)1, which results in nuclear entrapment of the ‘toxic’ mutant RNA and interacting RNA-binding proteins (such as MB...

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Bibliographic Details
Main Authors: Mahadevan, Mani S, Yadava, Ramesh S, Yu, Qing, Balijepalli, Sadguna, Frenzel-McCardell, Carla D, Bourne, T David, Phillips, Lawrence H
Format: Artigo
Language:Inglês
Published: 2006
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2909745/
https://ncbi.nlm.nih.gov/pubmed/16878132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng1857
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