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Catalysis of the microtubule on-rate is the major parameter regulating the depolymerase activity of MCAK
The kinesin-13, MCAK, is a critical regulator of microtubule dynamics in eukaryotic cells1. We have functionally dissected the structural features responsible for MCAK’s potent microtubule depolymerization activity. MCAK’s positively charged neck enhances its delivery to microtubule ends, not by tet...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2009
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2909650/ https://ncbi.nlm.nih.gov/pubmed/19966798 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.1728 |
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