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Catalysis of the microtubule on-rate is the major parameter regulating the depolymerase activity of MCAK
The kinesin-13, MCAK, is a critical regulator of microtubule dynamics in eukaryotic cells1. We have functionally dissected the structural features responsible for MCAK’s potent microtubule depolymerization activity. MCAK’s positively charged neck enhances its delivery to microtubule ends, not by tet...
में बचाया:
| मुख्य लेखकों: | , , , |
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| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
2009
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2909650/ https://ncbi.nlm.nih.gov/pubmed/19966798 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.1728 |
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