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Human metabolites of brevetoxin PbTx-2: Identification and confirmation of structure

Four metabolites were identified upon incubation of brevetoxin (PbTx-2) with human liver microsomes. Chemical transformation of PbTx-2 confirmed the structures of three known metabolites BTX-B5, PbTx-9 and 41, 43-dihydro-BTX-B5 and a previously unknown metabolite, 41, 43-dihydro-PbTx-2. These metabo...

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Hlavní autoři: Guo, Fujiang, An, Tianying, Rein, Kathleen S.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2909374/
https://ncbi.nlm.nih.gov/pubmed/20600229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.toxicon.2010.06.007
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