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INCREASED ENDOTHELIAL EXOCYTOSIS AND GENERATION OF ENDOTHELIN-1 CONTRIBUTES TO CONSTRICTION OF AGED ARTERIES
RATIONALE: Circulating levels of endothelin-1 (ET-1) and endogenous ET(A)-mediated constriction are increased in human aging. The mechanisms responsible are not known. OBJECTIVE: Investigate the storage, release and activity of ET-1 system in arteries from young and aged Fischer-344 rats. METHODS AN...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2010
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2909353/ https://ncbi.nlm.nih.gov/pubmed/20522806 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.109.210229 |
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