INCREASED ENDOTHELIAL EXOCYTOSIS AND GENERATION OF ENDOTHELIN-1 CONTRIBUTES TO CONSTRICTION OF AGED ARTERIES

RATIONALE: Circulating levels of endothelin-1 (ET-1) and endogenous ET(A)-mediated constriction are increased in human aging. The mechanisms responsible are not known. OBJECTIVE: Investigate the storage, release and activity of ET-1 system in arteries from young and aged Fischer-344 rats. METHODS AN...

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Bibliographic Details
Main Authors: Goel, Aditya, Su, Baogen, Flavahan, Sheila, Lowenstein, Charles J., Berkowitz, Dan E., Flavahan, Nicholas A.
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2909353/
https://ncbi.nlm.nih.gov/pubmed/20522806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.109.210229
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