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Trigenic neural crest-restricted Smad7 over-expression results in congenital craniofacial and cardiovascular defects
Smad7 is a negative regulator of TGFβ superfamily signaling. Using a three-component triple transgenic system, expression of the inhibitory Smad7 was induced via doxycycline within the NCC lineages at pre- and post-migratory stages. Consistent with its role in negatively regulating both TGFβ and BMP...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2909335/ https://ncbi.nlm.nih.gov/pubmed/20457144 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ydbio.2010.05.004 |
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