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Disruption of Smad4 in neural crest cells leads to mid-gestation death with pharyngeal arch, craniofacial and cardiac defects

TGFβ/BMP signaling pathways are essential for normal development of neural crest cells (NCCs). Smad4 encodes the only common Smad protein in mammals, which is a critical nuclear mediator of TGFβ/BMP signaling. In this work, we sought to investigate the roles of Smad4 for development of NCCs. To over...

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Bibliografske podrobnosti
Main Authors: Nie, Xuguang, Deng, Chu-xia, Wang, Qin, Jiao, Kai
Format: Artigo
Jezik:Inglês
Izdano: 2008
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2362382/
https://ncbi.nlm.nih.gov/pubmed/18334251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ydbio.2008.02.006
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