Metabolomic profiling can predict which humans will develop liver dysfunction when deprived of dietary choline

Choline is an essential nutrient, and deficiency causes liver and muscle dysfunction. Common genetic variations alter the risk of developing organ dysfunction when choline deficient, probably by causing metabolic inefficiencies that should be detectable even while ingesting a normal choline-adequate...

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Main Authors: Sha, Wei, da Costa, Kerry-Ann, Fischer, Leslie M., Milburn, Michael V., Lawton, Kay A., Berger, Alvin, Jia, Wei, Zeisel, Steven H.
Format: Artigo
Jezik:Inglês
Izdano: The Federation of American Societies for Experimental Biology 2010
Teme:
Research Communications
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2909293/
https://ncbi.nlm.nih.gov/pubmed/20371621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.09-154054
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