WNT4 is required for normal ovarian follicle development and female fertility

To study the role of WNT4 in the postnatal ovary, a mouse strain bearing a floxed Wnt4 allele was created and mated to the Amhr2(tm3(cre)Bhr) strain to target deletion of Wnt4 to granulosa cells. Wnt4(flox/−);Amhr2(tm3(cre)Bhr/+) mice had reduced ovary weights and produced smaller litters (P<0.05...

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Bibliographic Details
Main Authors: Boyer, Alexandre, Lapointe, Évelyne, Zheng, Xiaofeng, Cowan, Robert G., Li, Huaiguang, Quirk, Susan M., DeMayo, Francesco J., Richards, JoAnne S., Boerboom, Derek
Format: Artigo
Language:Inglês
Published: The Federation of American Societies for Experimental Biology 2010
Subjects:
Research Communications
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2909279/
https://ncbi.nlm.nih.gov/pubmed/20371632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.09-145789
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