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Embryonic vascular endothelial cells are malleable to reprogramming via Prox1 to a lymphatic gene signature

BACKGROUND: In vivo studies demonstrate that the Prox1 transcription factor plays a critical role in the development of the early lymphatic system. Upon Prox1 expression, early lymphatic endothelial cells differentiate from the cardinal vein and begin to express lymphatic markers such as VEGFR-3, LY...

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Detalhes bibliográficos
Main Authors: Kim, Harold, Nguyen, Vicky PKH, Petrova, Tatiana V, Cruz, Maribelle, Alitalo, Kari, Dumont, Daniel J
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2010
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2909156/
https://ncbi.nlm.nih.gov/pubmed/20584329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-213X-10-72
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