Catechol-O-Methyltransferase (COMT) Gene Variants: Possible Association of the Val158Met Variant With Opiate Addiction in Hispanic Women

Catechol-O-methyltransferase (COMT) catalyzes the breakdown of catechol neurotransmitters, including dopamine, which plays a prominent role in drug reward. A common single nucleotide polymorphism (SNP), G472A, codes for a Val158Met substitution and results in a fourfold down regulation of enzyme act...

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Main Authors: Oosterhuis, Bronson E., LaForge, K. Steven, Proudnikov, Dmitri, Ho, Ann, Nielsen, David A., Gianotti, Robert, Barral, Sandra, Gordon, Derek, Leal, Suzanne M., Ott, Jurg, Kreek, Mary Jeanne
格式: Artigo
語言:Inglês
出版: 2008
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2909109/
https://ncbi.nlm.nih.gov/pubmed/18270997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ajmg.b.30716
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