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Loss of a DNA binding site within the tail of prelamin A contributes to altered heterochromatin anchorage by progerin
Mutations in the LMNA gene that cause Hutchinson-Gilford progeria syndrome (HGPS) lead to expression of a protein called progerin with 50 amino acids deleted from the tail of prelamin A. In cells from patients with HGPS, both the amount and distribution of heterochromatin are altered. We designed in...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2010
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2908524/ https://ncbi.nlm.nih.gov/pubmed/20580717 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2010.05.032 |
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