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Kallikrein Expression and Cathelicidin Processing Are Independently Controlled in Keratinocytes by Calcium, Vitamin D(3), and Retinoic Acid

Cathelicidin has dual functions in the skin, acting as an innate antibiotic and as an immunomodulator in diseases such as rosacea and psoriasis. The serine proteases kallikrein 5 (KLK5) and kallikrein 7 (KLK7) control enzymatic processing of cathelicidin precursor in the skin and regulate the eventu...

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Main Authors: Morizane, Shin, Yamasaki, Kenshi, Kabigting, Filamer D., Gallo, Richard L.
Formato: Artigo
Idioma:Inglês
Publicado: 2010
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2908513/
https://ncbi.nlm.nih.gov/pubmed/20090765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jid.2009.435
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