Cathelicidin, kallikrein 5, and serine protease activity is inhibited during treatment of rosacea with azelaic acid 15% gel

BACKGROUND: Excess cathelicidin and kallikrein 5 (KLK5) have been hypothesized to play a role in the pathophysiology of rosacea. OBJECTIVE: We sought to evaluate the effects of azelaic acid (AzA) on these elements of the innate immune system. METHODS: Gene expression and protease activity were measu...

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Main Authors: Coda, Alvin B., Hata, Tissa, Miller, Jeremiah, Audish, David, Kotol, Paul, Two, Aimee, Shafiq, Faiza, Yamasaki, Kenshi, Harper, Julie C., Del Rosso, James Q., Gallo, Richard L.
Format: Artigo
Language:Inglês
Published: 2013
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3910251/
https://ncbi.nlm.nih.gov/pubmed/23871720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaad.2013.05.019
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