The selective hypoxia inducible factor-1 inhibitor PX-478 provides in vivo radiosensitization through tumor stromal effects

Hypoxia inducible factor-1 (HIF-1) promotes tumor cell adaptation to microenvironmental stress. HIF-1 is up-regulated in irradiated tumors and serves as a promising target for radiosensitization. We initially confirmed that the orally bioavailable HIF-1 inhibitor PX-478 reduces HIF-1 protein levels...

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Detalhes bibliográficos
Main Authors: Schwartz, David L., Powis, Garth, Thitai-Kumar, Arun, He, Yi, Bankson, James, Williams, Ryan, Lemos, Robert, Oh, Junghwan, Volgin, Andrei, Soghomonyan, Suren, Nishii, Ryuichi, Alauddin, Mian, Mukhopadhay, Uday, Peng, Zhenghong, Bornmann, William, Gelovani, Juri
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2908257/
https://ncbi.nlm.nih.gov/pubmed/19372568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-08-0981
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