Inactivation of IκB-kinase-β dependent genes in airway epithelium reduces tobacco smoke induced acute airway inflammation

We have examined the role of NF-κB regulated genes in airway epithelium in mediating tobacco smoke induced airway inflammation in studies of CC10-Cre(tg)/Ikkβ(Δ/Δ) mice in which NF-κB signaling through IκB-kinase-β (IKK-β) is selectively ablated in epithelial cells in the airway. CC10-Cre(tg/)Ikkβ(Δ...

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Main Authors: Lee, Sang Yeub, Miller, Marina, Cho, Jae Youn, Song, Dae Jin, Karin, Michael, Broide, David H
Formato: Artigo
Idioma:Inglês
Publicado: 2010
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2908188/
https://ncbi.nlm.nih.gov/pubmed/20494824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.intimp.2010.05.001
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