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Type-1 polarized dendritic cells primed for high IL-12 production show enhanced activity as cancer vaccines
While multiple pathways of dendritic cell (DC) maturation result in transient production of IL-12, fully mature DCs show reduced ability to produce IL-12p70 upon a subsequent interaction with Ag-specific T cells, limiting their in vivo performance as vaccines. Such “DC exhaustion” can be prevented b...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2009
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2907477/ https://ncbi.nlm.nih.gov/pubmed/19156413 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00262-008-0648-5 |
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