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Structures of minimal catalytic fragments of topoisomerase V reveals conformational changes relevant for DNA binding

Topoisomerase V is an archaeal type I topoisomerase that is unique among topoisomerases due to presence of both topoisomerase and DNA repair activities in the same protein. It is organized as an N-terminal topoisomerase domain followed by 24 tandem helix hairpin helix (HhH) motifs. Structural studie...

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Autors principals: Rajan, Rakhi, Taneja, Bhupesh, Mondragón, Alfonso
Format: Artigo
Idioma:Inglês
Publicat: 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2907367/
https://ncbi.nlm.nih.gov/pubmed/20637419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2010.03.006
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