Mechanisms Promoting Translocations in Editing and Switching Peripheral B Cells

V(D)J recombination assembles immunoglobulin (Ig) heavy or light chain (IgH or IgL) variable region exons in developing bone marrow B cells, while class switch recombination (CSR) exchanges IgH constant region exons in peripheral B cells. Both processes employ DNA double strand breaks (DSBs) repaire...

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Detalhes bibliográficos
Main Authors: Wang, Jing H., Gostissa, Monica, Yan, Catherine T., Goff, Peter, Hickernell, Thomas, Hansen, Erica, Difilippantonio, Simone, Wesemann, Duane R., Zarrin, Ali A., Rajewsky, Klaus, Nussenzweig, Andre, Alt, Frederick W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2907259/
https://ncbi.nlm.nih.gov/pubmed/19587764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature08159
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