PKCζ-regulated inflammation in the non-hematopoietic compartment is critical for obesity-induced glucose intolerance

Obesity-induced inflammation is critical for the development of insulin resistance. Here we show, that genetic inactivation of PKCζ in vivo leads to a hyperinflammatory state in obese mice that correlates with a higher glucose intolerance and insulin resistance. Previous studies implicated PKCζ in t...

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Autors principals: Lee, Sang Jun, Kim, Ji Young, Nogueiras, Ruben, Linares, Juan F., Perez-Tilve, Diego, Jung, Dae Young, Ko, Hwi Jin, Hofmann, Susanna M., Drew, Angela, Leitges, Michael, Kim, Jason K., Tschöp, Matthias H., Diaz-Meco, Maria T., Moscat, Jorge
Format: Artigo
Idioma:Inglês
Publicat: 2010
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2907185/
https://ncbi.nlm.nih.gov/pubmed/20620996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2010.05.003
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