Insulin/IGF-1 signaling mutants reprogram ER stress response regulators to promote longevity

When unfolded proteins accumulate in the endoplasmic reticulum (ER), the unfolded protein response is activated. This ER stress response restores ER homeostasis by coordinating processes that decrease translation, degrade misfolded proteins, and increase the levels of ER-resident chaperones. Ribonuc...

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Hlavní autoři: Henis-Korenblit, Sivan, Zhang, Peichuan, Hansen, Malene, McCormick, Mark, Lee, Seung-Jae, Cary, Michael, Kenyon, Cynthia
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2010
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2906894/
https://ncbi.nlm.nih.gov/pubmed/20460307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1002575107
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