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Insulin/IGF-1 signaling mutants reprogram ER stress response regulators to promote longevity
When unfolded proteins accumulate in the endoplasmic reticulum (ER), the unfolded protein response is activated. This ER stress response restores ER homeostasis by coordinating processes that decrease translation, degrade misfolded proteins, and increase the levels of ER-resident chaperones. Ribonuc...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2906894/ https://ncbi.nlm.nih.gov/pubmed/20460307 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1002575107 |
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