Absent in melanoma 2 is required for innate immune recognition of Francisella tularensis

Macrophages respond to cytosolic nucleic acids by activating cysteine protease caspase-1 within a complex called the inflammasome. Subsequent cleavage and secretion of proinflammatory cytokines IL-1β and IL-18 are critical for innate immunity. Here, we show that macrophages from mice lacking absent...

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Main Authors: Jones, Jonathan W., Kayagaki, Nobuhiko, Broz, Petr, Henry, Thomas, Newton, Kim, O'Rourke, Karen, Chan, Salina, Dong, Jennifer, Qu, Yan, Roose-Girma, Meron, Dixit, Vishva M., Monack, Denise M.
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2010
Ábhair:
Biological Sciences
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2906881/
https://ncbi.nlm.nih.gov/pubmed/20457908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1003738107
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