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Structural investigation of the C-terminal catalytic fragment of presenilin 1
The γ-secretase complex has a decisive role in the development of Alzheimer’s disease, in that it cleaves a precursor to create the amyloid β peptide whose aggregates form the senile plaques encountered in the brains of patients. Γ-secretase is a member of the intramembrane-cleaving proteases which...
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| Hlavní autoři: | , , , , , , , , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
National Academy of Sciences
2010
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2906861/ https://ncbi.nlm.nih.gov/pubmed/20445084 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1000778107 |
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