Structural investigation of the C-terminal catalytic fragment of presenilin 1

The γ-secretase complex has a decisive role in the development of Alzheimer’s disease, in that it cleaves a precursor to create the amyloid β peptide whose aggregates form the senile plaques encountered in the brains of patients. Γ-secretase is a member of the intramembrane-cleaving proteases which...

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Bibliographic Details
Main Authors: Sobhanifar, Solmaz, Schneider, Birgit, Löhr, Frank, Gottstein, Daniel, Ikeya, Teppei, Mlynarczyk, Krzysztof, Pulawski, Wojciech, Ghoshdastider, Umesh, Kolinski, Michal, Filipek, Slawomir, Güntert, Peter, Bernhard, Frank, Dötsch, Volker
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2010
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2906861/
https://ncbi.nlm.nih.gov/pubmed/20445084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1000778107
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