Methylation and silencing of miRNA-124 by EVI1 and self-renewal exhaustion of hematopoietic stem cells in murine myelodysplastic syndrome

By expressing EVI1 in murine bone marrow (BM), we previously described a myelodysplastic syndrome (MDS) model characterized by pancytopenia, dysmegakaryopoiesis, dyserythropoiesis, and BM failure. The mice invariably died 11–14 months after BM transplantation (BMT). Here, we show that a double point...

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Main Authors: Dickstein, Jerome, Senyuk, Vitalyi, Premanand, Kavitha, Laricchia-Robbio, Leopoldo, Xu, Peng, Cattaneo, Francesca, Fazzina, Raffaella, Nucifora, Giuseppina
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2010
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2906858/
https://ncbi.nlm.nih.gov/pubmed/20448201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1004297107
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