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Obligatory role in GTP hydrolysis for the amide carbonyl oxygen of the Mg(2+)-coordinating Thr of regulatory GTPases
When G-protein α subunits binds GTP and Mg(2+), they transition from their inactive to their active conformation. This transition is accompanied by completion of the coordination shell of Mg(2+) with electrons from six oxygens: two water molecules, the ß and γ phosphoryls of GTP, a helix-α1 Ser, and...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2906845/ https://ncbi.nlm.nih.gov/pubmed/20457940 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1004803107 |
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