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Zinc ions promote Alzheimer Aβ aggregation via population shift of polymorphic states
Although a key factor in Alzheimer’s disease etiology is enrichment of Zn(2+) in aggregates, and there are data suggesting that zinc promotes aggregation, how Zn(2+)-Aβ coordination promotes aggregation is elusive. Here we probe the structures and mechanisms through which Zn(2+) can affect amyloidos...
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| Main Authors: | , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
National Academy of Sciences
2010
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2906839/ https://ncbi.nlm.nih.gov/pubmed/20448202 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0913114107 |
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