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The role of toxin A and toxin B in Clostridium difficile-associated disease: Past and present perspectives

Recently, we constructed and characterized isogenic tcdA and tcdB mutants of a virulent Clostridium difficile strain and used a hamster model of disease to demonstrate that toxin B, not toxin A, is essential for virulence of this emerging pathogen. Earlier studies had shown that purified toxin A alo...

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Detalhes bibliográficos
Main Authors: Carter, Glen P, Rood, Julian I, Lyras, Dena
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2906822/
https://ncbi.nlm.nih.gov/pubmed/20664812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/gmic.1.1.10768
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