Structural basis for recognition of phosphodiester-containing lysosomal enzymes by the cation-independent mannose 6-phosphate receptor

Mannose 6-phosphate (Man-6-P)-dependent trafficking is vital for normal development. The biogenesis of lysosomes, a major cellular site of protein, carbohydrate, and lipid catabolism, depends on the 300-kDa cation-independent Man-6-P receptor (CI-MPR) that transports newly synthesized acid hydrolase...

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Bibliografiske detaljer
Main Authors: Olson, Linda J., Peterson, Francis C., Castonguay, Alicia, Bohnsack, Richard N., Kudo, Mariko, Gotschall, Russell R., Canfield, William M., Volkman, Brian F., Dahms, Nancy M.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2010
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2906551/
https://ncbi.nlm.nih.gov/pubmed/20615935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1004232107
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