Sequence Conversion by Single Strand Oligonucleotide Donors via Non-homologous End Joining in Mammalian Cells

Double strand breaks (DSBs) can be repaired by homology independent nonhomologous end joining (NHEJ) pathways involving proteins such as Ku70/80, DNAPKcs, Xrcc4/Ligase 4, and the Mre11/Rad50/Nbs1 (MRN) complex. DSBs can also be repaired by homology-dependent pathways (HDR), in which the MRN and CtIP...

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Hlavní autoři: Liu, Jia, Majumdar, Alokes, Liu, Jilan, Thompson, Lawrence H., Seidman, Michael M.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2010
Témata:
DNA and Chromosomes
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2906313/
https://ncbi.nlm.nih.gov/pubmed/20489199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.123844
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