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Interleukin-2 and Inflammation Induce Distinct Transcriptional Programs that Promote the Differentiation of Effector Cytolytic T Cells

Interleukin(IL)-2 and inflammation regulate effector and memory cytolytic T-lymphocyte (CTL) generation during infection. We demonstrate a complex interplay between IL-2 and inflammatory signals during CTL differentiation. IL-2 stimulation induced the transcription factor eomesodermin (Eomes), upreg...

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Detalhes bibliográficos
Main Authors: Pipkin, Matthew E., Sacks, Jilian A., Cruz-Guilloty, Fernando, Lichtenheld, Mathias G., Bevan, Michael J., Rao, Anjana
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2906224/
https://ncbi.nlm.nih.gov/pubmed/20096607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2009.11.012
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