FIRST-IN-HUMAN STUDY DEMONSTRATING PHARMACOLOGICAL ACTIVATION OF HEME OXYGENASE-1 IN HUMANS

Heme-oxygenase 1 (HO-1) degrades heme and protects against oxidative stress, but has not been pharmacologically induced in humans. In this randomized study (10 healthy volunteers), hemin (3 mg/kg. i.v in 25% albumin) increased plasma HO-1 protein concentration by 4–5 fold and HO-1 activity by ~15 fo...

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Main Authors: Bharucha, Adil E., Kulkarni, Anuja, Choi, Kyoung Moo, Camilleri, Michael, Lempke, Mary, Brunn, Gregory J., Gibbons, Simon J., Zinsmeister, Alan R, Farrugia, Gianrico
Format: Artigo
Language:Inglês
Published: 2009
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2906143/
https://ncbi.nlm.nih.gov/pubmed/19956091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/clpt.2009.221
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