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Differential Regulation of the PGC Family of Genes in a Mouse Model of Staphylococcus aureus Sepsis

The PGC family of transcriptional co-activators (PGC-1α [Ppargc1a], PGC-1β [Ppargc1b], and PRC [Pprc]) coordinates the upregulation of mitochondrial biogenesis, and Ppargc1a is known to be activated in response to mitochondrial damage in sepsis. Therefore, we postulated that the PGC family is regula...

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Autori principali: Sweeney, Timothy E., Suliman, Hagir B., Hollingsworth, John W., Piantadosi, Claude A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2905396/
https://ncbi.nlm.nih.gov/pubmed/20657826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0011606
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