A Toll-Like Receptor 2 Pathway Regulates the Ppargc1a/b Metabolic Co-Activators in Mice with Staphylococcal aureus Sepsis

Activation of the host antibacterial defenses by the toll-like receptors (TLR) also selectively activates energy-sensing and metabolic pathways, but the mechanisms are poorly understood. This includes the metabolic and mitochondrial biogenesis master co-activators, Ppargc1a (PGC-1α) and Ppargc1b (PG...

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Main Authors: Sweeney, Timothy E., Suliman, Hagir B., Hollingsworth, John W., Welty-Wolf, Karen E., Piantadosi, Claude A.
格式: Artigo
語言:Inglês
出版: Public Library of Science 2011
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3180377/
https://ncbi.nlm.nih.gov/pubmed/21966468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0025249
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