Gene Network Disruptions and Neurogenesis Defects in the Adult Ts1Cje Mouse Model of Down Syndrome

BACKGROUND: Down syndrome (DS) individuals suffer mental retardation with further cognitive decline and early onset Alzheimer's disease. METHODOLOGY/PRINCIPAL FINDINGS: To understand how trisomy 21 causes these neurological abnormalities we investigated changes in gene expression networks combi...

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Main Authors: Hewitt, Chelsee A., Ling, King-Hwa, Merson, Tobias D., Simpson, Ken M., Ritchie, Matthew E., King, Sarah L., Pritchard, Melanie A., Smyth, Gordon K., Thomas, Tim, Scott, Hamish S., Voss, Anne K.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2010
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2905390/
https://ncbi.nlm.nih.gov/pubmed/20661276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0011561
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