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Balanced ubiquitylation and deubiquitylation of Frizzled regulate cellular responsiveness to Wg/Wnt

Wingless (Wg)/Wnt has been proposed to exert various functions as a morphogen depending on the levels of its signalling. Therefore, not just the concentration of Wg/Wnt, but also the responsiveness of Wg/Wnt-target cells to the ligand, must have a crucial function in controlling cellular outputs. He...

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Библиографические подробности
Главные авторы: Mukai, Akiko, Yamamoto-Hino, Miki, Awano, Wakae, Watanabe, Wakako, Komada, Masayuki, Goto, Satoshi
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group 2010
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2905240/
https://ncbi.nlm.nih.gov/pubmed/20495530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2010.100
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