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Copper Binding Extrinsic to the Octarepeat Region in the Prion Protein

Current research suggests that the function of the prion protein (PrP) is linked to its ability to bind copper. PrP is implicated in copper regulation, copper buffering and copper-dependent signaling. Moreover, in the development of prion disease, copper may modulate the rate of protein misfolding....

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Bibliografiske detaljer
Main Authors: Walter, Eric D., Stevens, Dan J., Spevacek, Ann R., Visconte, Micah P., Rossi, Andrew Dei, Millhauser, Glenn L.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2905140/
https://ncbi.nlm.nih.gov/pubmed/19538144
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