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The Affinity of Copper Binding to the Prion Protein Octarepeat Domain: Evidence for Negative Cooperativity
The prion protein (PrP) binds Cu(2+) in its N-terminal octarepeat domain, composed of four or more tandem PHGGGWGQ segments. Previous work from our laboratory demonstrates that copper interacts with the octarepeat domain through three distinct coordination modes at pH 7.4, depending upon the precise...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2006
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2905157/ https://ncbi.nlm.nih.gov/pubmed/17059225 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi060948r |
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