Lataa...

The Affinity of Copper Binding to the Prion Protein Octarepeat Domain: Evidence for Negative Cooperativity

The prion protein (PrP) binds Cu(2+) in its N-terminal octarepeat domain, composed of four or more tandem PHGGGWGQ segments. Previous work from our laboratory demonstrates that copper interacts with the octarepeat domain through three distinct coordination modes at pH 7.4, depending upon the precise...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Walter, Eric D., Chattopadhyay, Madhuri, Millhauser, Glenn L.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2006
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2905157/
https://ncbi.nlm.nih.gov/pubmed/17059225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi060948r
Tagit: Lisää tagi
Ei tageja, Lisää ensimmäinen tagi!