Trafficking-Competent KCNQ1 Variably Influences the Function of HERG Long QT Alleles

BACKGROUND: Mutations in the KCNQ1 and HERG genes cause the Long QT Syndromes, LQTS1 and LQTS2, due to reductions in the cardiac repolarizing I(Ks) and I(Kr) currents, respectively. It was previously reported that KCNQ1 co-expression modulates HERG function by enhancing membrane expression of HERG,...

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Huvudupphovsmän: Hayashi, Kenshi, Shuai, Wen, Sakamoto, Yuichiro, Higashida, Haruhiro, Yamagishi, Masakazu, Kupershmidt, Sabina
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2010
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2904856/
https://ncbi.nlm.nih.gov/pubmed/20348026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.hrthm.2010.03.038
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